Nuclear magnetic resonance spectroscopy of excised human hearts

Proton Nuclear Magnetic Resonance Spectroscopy

18. Nuclear Magnetic Resonance Spectroscopy

Nuclear Magnetic Resonance (NMR) is a spectroscopic technique widely used by organic chemists. NMR provides details about the location, number and environment of specific types of atoms within a sample. The proper interpretation of this information allows detailed chemical structures to be discerned. The same basic instrumentation used in this week’s experiment is used in physician offices when...

Evaluation of nuclear magnetic resonance spectroscopy variability

Introduction: The intrinsically high sensitivity of Magnetic Resonance Spectroscopy (MRS) causes considerable variability in metabolite quantifi cation. In this study, we evaluated the variability of MRS in two research centers using the same model of magnetic resonance image scanner. Methods: Two metabolic phantoms were created to simulate magnetic resonance spectra from in vivo hippocampus. T...

Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts.

Determination of myocardial infarct size is important for clinical management of patients with ischemic heart disease and for research on limiting infarct size. Nuclear magnetic resonance (NMR) imaging permits tomographic depiction of the distribution of mobile tissue protons. NMR images have demonstrated high spatial resolution and contrast. To evaluate the potential of this technique in measu...

Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy: A Systematic Review

Background: Analysis of biofluids provides a unique window into the biochemical status of a living organism since the composition of a given biofluid will be modulated according to the level of function of the cells that are intimately concerned with its manufacture and secretion. One of the most successful approaches to biofluid analysis has been the application of NMR spectroscopy. Objective...